Hormone free bovine immunoglobulin concentrate
Cognizin Kyowa Hakko Citicoline
DMAE (as DMAE bitartrate)
DHA (docosahexaenoic acid)
Fo-ti (polygonum multiflorum root)
Hormone-Free Bovine Immunoglobulin Concentrate
Immunoglobulins are antibodies – bioactive proteins that your immune system uses to fight against intruding viruses and bacteria. Over 60 clinical studies have been published on the therapeutic effects of Immunoglobulins. The hormone-free immunoglobulin concentrate in I.N. Extreme Energy™ is similar to the colostrum found in breast milk, serving both as a supply of high-quality, absorptive protein and as an immune booster. It delivers antibodies to your gut where they fight against disease-causing organisms and inflammation, allowing your body more energy for other tasks. Unlike antibiotics, which destroy both good and bad bacteria, immunoglobulins only work against the bad bacteria, for optimal immune health.
Immunoglobulins have also been shown to help improve liver function, and reduce LDL cholesterol (the kind associated with heart disease)while keeping HDL, the "good" cholesterol, levels constant.
Dietary plasma proteins modulate the immune response of diffuse GALT. J Nutr Vol 138 pp 533. Perez Bosque et al., 2008.
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Spray-dried animal plasma prevents the effects of SEB on intestinal barrier function in rats. J Nutr 196 pp 2838 2843. Perez-Bosque et al.
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Med 12 pp 1365 1371. Brenchley et al 2006.
Alteration of somatotropic function by proinflammatory cytokines. J Anim Sci 82 pp E100. Frost and Lang 2004.
Effect of animal plasma proteins on intestinal damage and recovery. J Nutr Biochem Vol 18 pp 778 to 784. Moon et al 2007.
Cognizin Kyowa Hakko Citicoline
Citicoline is synthetic CDP-choline, an organic molecule made by your body and present in all your cells. It has been shown to enhance memory and cognition by increasing the levels of several key neurotransmitters, including acetylcholine and dopamine. It also protects your neuronal membranes and increases energy production in the prefrontal cortex of your brain. Cognizin Kyowa Hakko Citicoline is a high quality source of choline made in the USA and known for its purity and stability. Cognizin Kyowa Hakko Citicoline has been shown to protect neural tissue from damaging free radicals, help protect visual function, and protect against age-related cognitive impairment.
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Enhancement by cytidine of membrane phospholipid synthesis. Journal of Neurochemistry. 59(1):338-43, 1992. G-Coviella IL. & Wurtman RJ.
Cytidine-5'-diphosphocholine improves visual acuity, contrast sensitivity and visually-evoked potentials of amblyopic subjects. Current Eye Research. 17(2):141-8, 1998. Porciatti V. Schiavi C. Benedetti P. Baldi A. & Campos EC.
Lipid alterations in transient forebrain ischemia: possible new mechanisms of CDP-choline neuroprotection. Journal of Neurochemistry. 75(6):2528-35, 2000. Rao AM. Hatcher JF. & Dempsey RJ.
Cytidine-5'-diphosphocholine (citicoline) improves retinal and cortical responses in patients with glaucoma. Ophthalmology. 106(6):1126-34, 1999. Parisi V. Manni G. Colacino G. & Bucci MG.
Effect of CDP-choline on learning and memory processes in rodents. Methods & Findings in Experimental & Clinical Pharmacology. 14(8):593-605, 1992. Petkov VD. Mosharrof AH. Kehayov R. Petkov VV. Konstantinova E. & Getova D.
DHA (Docosahexaenoic acid) is a naturally occurring omega 3 fatty acid commonly found in fish oil. While the human body is incapable of making DHA, it is vital to health, particularly to brain and neuron function, as 50% of the weight of the neuronal plasma membrane is made of DHA. DHA deficiency is associated with cognitive decline, increased neural cell death and depression.
DHA is also important to general cellular health. It is literally a building block of cell membranes and influences cellular elasticity, ion permeability (and therefore cellular ‘charge’) and membrane organization of cells. It also functions as an anti-inflammatory agent, and recent research has shown that DHA supplementation combined with exercise elevates the capacity of the adult brain for axonal growth, synaptic plasticity, and cognitive function.
Essential Fatty Acids, DHA and the Human Brain. Indian J Pediatr 2005; 72 (3): 239-242. Meharban Singh.
N-3 Fatty acids and the inflammatory response – biological background. Eur Heart J Supplements 2001; 3 (Suppl D): D42-D49. De Caterina, R and Basta, G
Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study. Am J Clin Nutr 87 (6): 1616–1622. Vedin I, et al. (1 June 2008).
Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol. Psychiatry 62 (1): 17–24. McNamara RK, Hahn CG, Jandacek R, et al. (2007).
Comparative effects of DHA and EPA on cell function. Pharmacology & Therapeutics, Volume 122, Issue 1, April 2009, Pages 56-64. Renata Gorjão, Anna Karenina Azevedo-Martins, Hosana Gomes Rodrigues, Fernando Abdulkader, Manoel Arcisio-Miranda, Joaquim Procopio, Rui Curi.
Exercise contributes to the effects of DHA dietary supplementation by acting on membrane-related synaptic systems. Brain Research, In Press, Corrected Proof, Available online 13 May 2009. Gabriela Chytrova, Zhe Ying, Fernando Gomez-Pinilla
Dimethylaminoethanol (DMAE) is an organic compound found in certain fish, and it produces choline in the brain. Adequate choline is an important part of cellular health, as it is essential in the formation of cell membranes. DMAE is currently used to treat ADD and ADHD, and there is a hypothesis that DMAE helps retard aging by protecting cell membrane and structure, and that it may have anti-cancer properties, though studies are not conclusive.
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Electron spin resonance spectroscopic demonstration of the hydrdoxyl free radical scavenger properties of dimethylarninoethanol in spin trapping experiments confirming the molecular basis for the biological effects of centrophenoxine. Arch. Gerontol. Geriatr., 3 (1984) 297--310. I. Zs.-Nagy and R.A. Floyd.
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Gotu Kola (Centella Asiatica) is a medicinal plant that grows in many parts of Asia and is used in Ayurvedic medicine and traditional Chinese Medicine to nourish the nervous system, improve concentration and memory, increase brain circulation and overall vitality. It has been shown to have anti-viral, anti-oxidant and anti-inflammatory properties, as well as to help in wound healing. Preliminary studies have also confirmed that it has memory and cognitive enhancing effects, and that it reduces anxiety and stress response.
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Chemical, Pharmacological and Clinical Profile of The East Asian Medical Plant Centella asiatica. Phytomedicine 2000 Oct; 7(5):427-48. Brinkhause, B., Lindner, M., et al.
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Fo-ti (Polygonum Multiflorum) is a natural herb that has long been used in traditional Chinese medicine to treat cognitive impairment. It has been shown to be an effective antioxidant, to improve memory and protect brain function.
Stilbene Glycosides from the Roots of Polygonum Multiflorum Thunb. and Their Antioxidant Activities. Journal of Food Lipids 13 (2): 131–144. L.V. Li-Shuang, Xiaohong Gu, Chi-Tang Ho (June 2006).
Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice. Pharmacology Biochemistry and Behavior, Volume 82, Issue 2, October 2005, Pages 345-352. Xia Li, Kinzo Matsumoto, Yukihisa Murakami, Yasuhiro Tezuka, Yingliang Wu, Shigetoshi Kadota.
Protective effect of Polygonum multiflorum Thunb on amyloid β-peptide 25-35 induced cognitive deficits in mice. Journal of Ethnopharmacology, Volume 104, Issues 1-2, 8 March 2006, Pages 144-148 Min-Young Um, Won-Hee Choi, Ji-Yun Aan, Sung-Ran Kim, Tae-Youl Ha
Antioxidant activity of stilbene glycoside from Polygonum multiflorum Thunb in vivo. Food Chemistry, Volume 104, Issue 4, 2007, Pages 1678-1681. LiShuang Lv, XiaoHong Gu, Jian Tang, Chi-Tang Ho
Beneficial effects of different Polygonum multiflorum Thunb extracts on memory and hippocampus morphology. J Nutr Sci Vitaminol (Tokyo) 2002;48:491 – 7. Chan YC, Cheng FC, Wang MF.
2,2-Diphenyl-1-picrylhydrazyl radical- scavenging active components from Polygonum multiflorum Thunb. J Agric Food Chem 1999;47:2226 – 8. Chen Y, Wang MF, Rosen RT, Ho C.